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NIM-for-AlphaFold2-Multimer

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NIM for AlphaFold2-Multimer

Type: Microservice Tags: NVIDIA, NIM, BioNeMo, AlphaFold2-Multimer, protein complexes, MSA, drug discovery, computational biology Related: NVIDIA-BioNeMo, NVIDIA-NIM, NIM-for-MSA-Search, NIM-for-AlphaFold2, NIM-for-OpenFold2, NIM-for-OpenFold3, NIM-for-Boltz2, NIM-for-ProteinMPNN, NVIDIA-Clara, NVIDIA-AI-Enterprise, NGC Sources: https://docs.nvidia.com/nim/bionemo/alphafold2-multimer/latest/overview.html; https://docs.nvidia.com/nim/bionemo/alphafold2-multimer/latest/index.html Last Updated: 2026-04-29

Summary

NIM for AlphaFold2-Multimer is NVIDIA’s NIM microservice for predicting protein structures from multiple protein sequences. It is the multimer/complex counterpart to NIM-for-AlphaFold2, with endpoints and deployment guidance for sequence-to-structure, sequence-to-MSA, and MSA-to-structure workflows over multiple sequences.

Detail

The current docs describe AlphaFold2-Multimer as a fast, accurate model behind a consistent NIM API for predicting protein structure in CADD workflows. The NIM can predict protein structures from multiple protein sequences, predict MSAs for multiple sequences, or predict a structure from pre-computed MSAs.

This page is useful when the query is about protein-protein complexes or multimeric AlphaFold2 workflows. It stays separate from NIM-for-AlphaFold2 because the input and use case are different: multiple interacting sequences rather than a single protein chain.

Connections

  • NVIDIA-BioNeMo - BioNeMo is the NVIDIA life-sciences platform that includes AlphaFold2-Multimer NIM.
  • NVIDIA-NIM - delivered as an NVIDIA NIM microservice.
  • NIM-for-MSA-Search - paired MSA search supports multimer and protein-complex structure prediction workflows.
  • NIM-for-AlphaFold2 - single-chain AlphaFold2 NIM.
  • NIM-for-OpenFold2 - open AlphaFold2-style protein structure prediction NIM.
  • NIM-for-OpenFold3 - all-atom biomolecular complex prediction NIM.
  • NIM-for-Boltz2 - biomolecular complex and binding-affinity prediction NIM.
  • NIM-for-ProteinMPNN - sequence-design NIM adjacent to generated or predicted protein structures.
  • NVIDIA-Clara - healthcare/life-sciences umbrella platform.
  • NVIDIA-AI-Enterprise - enterprise support and production deployment context.
  • NGC - distribution path for NIM containers and model assets.

Source Excerpts

  • “multiple protein sequences”
  • “computer-aided drug discovery”
  • “pre-computed MSA”

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